Anika Therapeutics, Inc. Price & Performance (ANIK)

Thank you, Silvi. Good evening, and thank you for joining us for Anika's fourth quarter year end twenty twenty four conference call and webcast. I'm Matt Hall, Anika Director of Corporate Development and Investor Relations. Our earnings press release was issued earlier this afternoon is available on our Investor Relations website located at www.anica.com. As are the supplementary PowerPoint slides that will be used for the discussion today. With me on the call today are Doctor. Cheryl Blanchard, President and Chief Executive Officer and Steve Griffin, Executive Vice President Chief Financial Officer and Treasurer who will present our fourth quarter and year end 2024 financial results and business highlights. Please take a moment and open the slide presentation and refer to Slide number two. Before we begin, please understand that certain statements made during the call today constitute forward looking statements as defined in the Securities Exchange Act of 1934. These statements are based on our current beliefs and expectations and are subject to certain risks and uncertainties. The company's actual results could differ materially from any anticipated future results, performance or achievements. We make no obligation to update these statements should future financial data or events occur that differ from the forward looking statements presented today.

Please also see our most recent SEC filings for more information about risk factors that could affect our performance. In addition, during the call, we may refer to several adjusted or non GAAP financial measures. Which may include adjusted gross margin, adjusted EBITDA, adjusted net income from continuing operations, and adjusted earnings per share from continuing operations. Which are used in addition to results presented in accordance with GAAP financial measures. [indiscernible] We believe that non GAAP measures provide an additional way of viewing asset But when considered with GAAP financial measures and the reconciliation of GAAP measures, they provide an even more complete understanding of our business. A reconciliation of these adjusted non GAAP financial results to the most comparable GAAP measurements are available at the end of the presentation slide deck in our fourth quarter and full year 2024 press release. [indiscernible] And now I'd like to turn the call over to our President and CEO, Doctor. Cheryl Blanchard. Cheryl? Thanks, Matt. Good afternoon, everyone, and thank you for joining us.

Please turn to Slide three. [indiscernible] I'm pleased to report since our last call that we've made meaningful progress advancing our strategic initiatives and refocusing our strategy. As we've communicated, a key objective has been to focus our human and financial capital on our most promising opportunities to create shareholder value. As a result, we divested Arthro Surface in Q4 of twenty twenty four and last week announced These divestitures align with our focus to capitalize on our core products that provide us with the best value building opportunities including the Integrity implant system and The U. S. Approvals of Hylofest and Singhal. I'll start today by sharing our financial results for the quarter and full year. Overall revenue in the fourth quarter was $30,600,000 up 1% compared to the same period in 2023. For the year, revenue was $119,900,000 a slight decrease of 1% compared to 2023. Commercial channel revenue was up 25% in the quarter and 17% for the full year while OEM channel revenue decreased by 8% for the quarter and the full year consistent with our expectations. And 16% growth for the full year This success was driven by continued geographic expansion and market share gains.

Highlighting our robust international presence Our efforts to penetrate new markets and and we are committed to further expanding our global footprint. In 2024, we made significant progress across the refocused company. We executed on key objectives in our commercial channel fueled by continued gains in our international OA pain management business and further acceleration of Integrity. We sharpened our strategic focus on based products and achieved important milestones in our commercial, regulatory and clinical trial goals.

During the quarter, Integrity realized more than 40% sequential growth with more than 300 surgeries performed in the quarter and now over 1,000 globally since its launch. This marks the third sequential quarter that we've achieved greater than 40% quarter over quarter growth. This impressive growth is attributed to the superior regenerative properties and mechanical strength of Integrity compared to collagen scaffolds. These key attributes of integrity have resulted in a strong pull from surgeons. In February, we released a white paper summarizing the early clinical results from our first post market study of 29 patients with partial and full thickness rotator cuff tears. [indiscernible] The results showed significant and clinically meaningful improvements in pain and and further improvements in pain range of motion and strength at six months. With no evidence of any retears at six months or device related complications. This data has been well received, leading to increased adoption and we continue to hear positive feedback from both surgeons and their patients. As a result of our successful commercial launch, we captured more than one percent of the twenty twenty four U. S. Soft tissue augmentation procedures in our first six months of full market release. [indiscernible] We believe Integrity will continue to drive significant commercial channel revenue contributing to our long term revenue targets To further accelerate growth in our commercial channel, we continue to advance our integrity technology platform to add additional near term regenerative solutions products to our pipeline.

As mentioned on our Q3 call, we've partnered with a team of leading surgeons to develop new shapes, sizes and configurations of integrity. We are on track to begin introduction of those new product line extensions to The U. S. Market later this year.

Additionally, we've enrolled our first patient in the prospect clinical study for INTEGRITY, [indiscernible] This study will provide valuable real world evidence will enhance Integrity's position in the market support expanding sales efforts and marketing efforts, and drive further commercial growth. [indiscernible] anticipate that the data from this study will reinforce the clinical benefits and safety profile of INTEGRITY further solidifying its market position. Data from this study will also be used for submission to the EU for MDR approval. We also made significant regulatory and clinical progress with our key pipeline programs. In January 2025, we filed the second PMA module for Hyalofast, our single stage off the shelf proprietary hyaluronic acid scaffold for cartilage repair. Which is already sold in over 35 countries outside The U. S. We expect to file the third and final clinical module in the Second Half Of This Year With A U. S. Launch planned by 2026. We also reached another key regulatory milestone for HILOFAST, receiving MDR approval in February. Hyalofast has shown continued market leading positions geographies where it sold and we're excited about its potential to address significant unmet needs for cartilage repair patients in The U. S. [indiscernible] Finally, Singhal, our fast acting, long lasting non opioid OA pain product also saw important advancements.

We held a productive Type C meeting with the FDA in February to help finalize the bioequivalence bridging study design. We are awaiting formal feedback from the meeting and plan to share further updates to investors as we move forward. We also started the final nonclinical toxicology testing in Q1 of this year.

The feedback from international markets has been overwhelmingly positive we believe Singhal will be a market driving force in the next generation OA pain management segment. [indiscernible] And with that, I'll now turn the call over to Steve for a detailed review of our financial results. Thank you, Cheryl.

Before I review the quarter, I'll start by providing some further details regarding the recently announced sale of the Parkus business. In line with our announcement in October of last year, we completed the simultaneous signing and closing of the Parka Sports Medicine business on Friday, March 7, to MidActa, a well respected and growing global orthopedic company. This deal positions the Parkus business to continue to serve patients while enabling Anika to prioritize our investments on our highest growth higher margin hyaluronic acid technologies. The transaction closed with cash received at closing subject to customary post closing networking capital condition. We expect to support the Parkus and Medacta teams through a transition services agreement in 2025 to ensure continuity of business services. We have now successfully closed on the sales of Arthur Surface and Parkus. Both businesses will be included in the discontinued operations income statement and the associated assets and liabilities have been reclassed to held for sale in the respective balance sheet periods. This strategic move including an all cash transaction at closing for the second sale, allows us to streamline our operations and focus on our core strengths. While providing these businesses with new opportunities under their new leadership.

Going forward, our continuing operations will reflect the core products of Anika's hyaluronic acid future. And key reconciliations to quarter results are provided in the appendix materials of today's presentation. I'll now provide updates on the fourth quarter of twenty twenty four. Please refer to Slide four of the presentation. In the fourth quarter, Anika generated $30,600,000 in total revenue, up 1% versus the same period in 2023. Revenue in the commercial channel which includes our highly differentiated products, sold globally through commercial leaders, direct sales representatives and independent distributors was up 25% year over year to $10,900,000 slightly ahead of our previously provided guidance. We continue to execute well on our international OA paying gross with sales up 22% year over year led by MONOVISC and CINGAL. Also in our commercial channel, Regenerative Solutions grew 32% year over year and continues to form a solid foundation for future growth as we exceed our initial launch expectations for Integrity. Integrity sales grew by more than 40% sequentially for the third straight quarter And since commercial launch, we have completed more than 1,000 cases. Integrity captured more than 1% of the domestic rotator cuff augmentation market in 2024. And is poised to continue to grow as a result of our differentiated technology.

Revenue in the OEM channel which includes our domestic OA pain and non orthopedic products, sold under long term agreements decreased 8% in the fourth quarter to $19,700,000 in line with guidance. The decline was primarily due to lower U. S. Sales from J and J which faced lower volumes and competitive pricing pressures. Despite reduced market access and lower pricing, MONOVISC and ORTHOVISC remain market leaders in The U. S. In this market, multi injection continues to siege market share to single injection. While both products pricing are more reflective of the competitive environment. Non orthopedic revenue declined in the quarter driven by lower sales of mature products. Fourth quarter gross margin was 56% down 13 points from last year. Adjusted gross margin, excluding legacy product rationalization charges, was 58% down 11 points versus last year. One time legacy program expenses and the product mix sold during the quarter equally contributed to the decrease. Operating expenses in the fourth quarter totaled $17,800,000 down $1,000,000 or 7% as compared to 2023. Selling, general and administrative expenses were lower by 16% as compared to 2023 driven by cost actions taken earlier in the year Research and development expenses of $6,500,000 were higher by 18% compared to 2023, primarily as a result of the one time FDA filing fee for Hyalofast in October.

Continuing operations generated $3,600,000 of adjusted EBITDA, down 44% as compared to 2023 primarily as a result of the one time legacy program expenses. Product mix and higher research and development, Discontinued operations in the fourth quarter included a one time non cash impairment charge associated with the sale of Parkus Medical. For the quarter, discontinued operations generated $100,000 in adjusted EBITDA. As a note, in accordance with GAAP, certain corporate expenses for accounting, human resources, IT and legal remain in continuing operations and have not been allocated to the discontinued operations P and L. For any of our recasted financials. Total adjusted EBITDA for Anika was $3,600,000 in line with our previous guidance. In the first quarter of twenty twenty five, we will continue to include the results from Parkus Medical and discontinued operations in addition to any transition services related to this [indiscernible] For the buyer. We expect that by year end 2025, there will be no further discontinued operations activities. Now turning to cash and liquidity. We generated $1,600,000 in operating cash flow this quarter. Down from $3,600,000 last year. Primarily due to lower profitability. In the second half of twenty twenty four, we generated $6,600,000 in operating cash flow as a result of stronger working capital management, Capital expenditures in the quarter were $1,300,000 down $500,000 from the prior year.

We are investing in our Massachusetts manufacturing facility. To support higher expected output of OA pain and regenerative solutions products.

Offset by lower expenditures for Arthro Surface and Parkus in the prior year. As previously communicated, we initiated a 10b5-one stock repurchase plan in May twenty twenty four In the fourth quarter, we purchased $5,600,000 in common stock, As of last week, we completed the $15,000,000 initial share repurchase. Earlier than our expected June 2025 deadline. We remain committed to completing our total share repurchase plan 2026 and we'll share more information when we're in a position to do so. We ended the fourth quarter with $56,000,000 in cash, and no debt. Now to Slide five. For the full year, Anika generated revenue of 100.91 hundred and $19,900,000 a decline of 1% compared to prior year and in line with our full year guidance. Our commercial channel grew 17% to $42,100,000 16% in the year slightly ahead of our expectations. This growth highlights the outstanding work of our international sales team distributors in gaining market share with Monovisk, ORTHOVISC and CINGAL. All three of which grew year over year led by MONOVISC and CINGAL. The launch of Integrity was the other primary driver of year over year revenue growth. Our commercial channel has grown at an average compounded annual growth rate of 17% for the last three years organically.

And now represents 35% of total company continuing operations revenue. Up from 24% in 2021. OEM channel revenue was $77,800,000 in 2025, down 8% year over year in line with prior guidance. Competitive market pressures for MONOVISC and ORTHOVISC in The U. S. Drove the majority of this reduction. GAAP gross margin for the year was 63%, down from 68% last year. Adjusted gross margin, excluding product rationalization, was 64%. Down from 69% last year. Mainly driven by certain legacy program expenses and the impact of product mix. Total operating expenses were $81,000,000 down $1,000,000 year over year. R and D spend was higher by $4,000,000 driven by the Hi LoFAST submission and Integrity product launch and line extensions. Partially offset by $4,000,000 of cost reductions from general and administrative expenses. Adjusted EBITDA from continuing operations was $15,500,000 and adjusted EBITDA from discontinued operations was $2,300,000 Combined for the full year total company adjusted EBITDA was in line with our previously provided range of $16,000,000 to $18,000,000 As a reminder, certain corporate expenses for accounting, HR, IT and legal remain in continuing operations have not been allocated to the prior periods. For the discontinued operations P and L. Since the third quarter, Anika has generated $6,600,000 in operating cash flow.

For the full year, we generated $5,400,000 significantly improving from the $1,700,000 operating cash usage in 2023. Stronger working capital management of our core products and reduced investments into our two divested businesses have driven this positive change. [indiscernible] on Slide six, I'll review our full year financial outlook for 2025. For the year, we anticipate our commercial channel to deliver between $47,000,000 and $49,500,000 of revenue. An increase of 12% to 18% in 2025. This growth is driven by expanding market share for Integrity, and increasing international sales of our OA pain management products. In our OEM channel, we now anticipate revenue to be at the lower end of the range of $64,000,000 to $68,500,000 a range of 12% to 18% decline versus 2024. This update is based on the initial 2025 pricing insights from J and J for OrthoVisk and Monovisk. As a reminder, J and J has full control of sales, marketing and pricing activities for these products in The United States. And Anika receives royalties based on J and J's and user pricing. We expect in the coming quarters to further tighten this revenue range. As expected, However, looking ahead to 2026 and 2027, we expect revenue in the OEM channel to remain stable or slightly lower as pricing for Montovisk and Orthovisk stabilize more in line with the market and historic trends.

Now turning to profitability. Based on J and J's new pricing, we expect adjusted EBITDA for 2025 to be between 810%. Lower pricing for Montovisk and Orthovisk has directly impacted our royalties, and we continue to seek ways to reduce our operating expenses to drive efficiency. Our 2025 adjusted EBITDA accounts for investments in our regenerative solutions portfolio, and the necessary toxicity studies for the CINGAL FDA filing. We are awaiting formal feedback from the FDA on BioCulben's testing for CIGAL. Once we receive feedback from our Type C meeting with them, we will update you on our next quarterly call on any potential R and D expenses required in 2025. In summary, 2024 was a year of significant progress for Anika. We are confident that the steps we have taken will serve to increase our growth profile for years to come. We believe the company is now in a substantially better position to drive long term sustainable growth as we continue to execute on our commercial and product development goals and objectives. With that, I'll turn it back over to Cheryl.

Thanks, Steve. So as you've heard today, we're making excellent progress driving our refocused strategy and have line of sight to significant shareholder value creation in the not so distant future as we What do we need to do for that to happen? We need to continue to grow international OA pain products and integrity domestically. And we need to get HILOFAST approved and move FINAL to an NDA filing. I'm more confident than ever that we can accomplish these critical objectives. As we achieve these goals, the impact and importance of the long standing J and J and Anika contracts will be substantially lessened as Anika will be a drastically different company. Moreover, our financial structure is on solid footing and we have the means to deliver on these goals without the need to raise capital. We look forward to sharing our progress in the coming quarters. Finally, I'd like to sincerely thank all the team members left the company as part of the Arthur Surface and Parkus divestitures [indiscernible] I wish them all the best as they continue to serve patients. I would also like to thank those at Anika who contributed to our financial and furthered our programs.

Finally, I would also like to thank the distributors and surgeons who have remained committed to Anika and we look forward to continuing to work together. And with that, we'll open up the line for questions.

Thank you. First, we will hear from Jim Souda at Sidoti and Company. Please go ahead, Jim.

Hi, good afternoon. Thanks for taking the questions. I'm sorry if I missed this, but what were the one time legacy programming expenses you referred to?

Some program expenses related to legacy So kind of one time in nature, Jim, in relation to the quarter, not something we expect continue going forward.

And was the magnitude of that?

It's a couple of million dollars, but it's not material. So I'd say between $1,000,000 and $2,000,000 And then G and A, down quite a bit from prior quarters. Because of the divestitures. That SG and A of around $11,000,000 $12,000,000 Is that a good proxy for 2025 or they're one times in that?

I think that's a good approximation going forward. The numbers that you see here on our continuing operations basis, so they reflect sort of the go forward of what Anika is. With our focus around hyaluronic acid. Obviously, Jim, we're trying to remain very focused around being lean, but in the same respect, this is the right representation of where the business is today.

And it sounds like there were some charges in R and D for [indiscernible] Can you tell me about how big those were? Yes. The Hyalofas filing fee was about $600,000 That was for the first module that was submitted back in October of last year. That's a one time filing fee.

All right. So if you take that out $6,000,000 in R and D, is that a good proxy for that loan?

Yes. I think that's a fair way to look at it. I mean R and D is trending towards the higher end when we enter into 2025. And that's primarily due to the fact that we have the continued work on the completion of Hialeah Fast, from a submission standpoint in The U. S. As well as the post market clinical trial for INEGRITY and the work associated with toxicity for Cyngdol. So R and D is ticking a little higher when we enter into 2025 versus 2024, but if you want back that number out of your fourth quarter number on R and D, you could.

Okay. And then lastly, on Singhal, do you expect any major R and D expense in 2025 for Singhao?

We've included I think I included this in my remarks just a couple of minutes ago, but we've already built in the costs associated with the toxicity study. So as you know, there's sort of two filing items associated with Singhal. One of them was the toxicity for MONOVISC. That work was kicked off and that's assumed. The other one is around bioequivalents for the TH. We'll give an update, I think, when we get to the first quarter earnings call, that's what I referenced, in terms of if there are any expenses from an R and D perspective. Exactly how much those will be.

Okay. But it sounds like the bulk of that work the bulk of the expenses are done at this point. It's just I guess, responding to questions from the FDA?

Certainly, yes. I mean, in comparison to what this total program has cost over time, definitely, that's the right way conclude.

Okay. All right. Thank you.

Thank you. Next question will be from Mike Petusky at Barrington Research. Please go ahead, Mike.

Hi. So Cheryl, I guess from in terms of the integrity progress do you have any anything you can share in terms of sort of uptake from surgeons meaning like is a handful of guys sort of doing the vast majority of these or are you starting to sort of build a base of surgeons and any obviously any quantification of any progress there would be interesting. Thanks.

Yes, great question, Mike. Thanks. What I would tell you is that our uptake of integrity is being driven by a broad set of surgeons using it. We obviously have a core group of surgeons who were the initial release surgeons who have continued to adopt Integrity in their practices. But we have built out a very strong group of surgeons brought a lot of new users, new relationships into Anika. I'll tell you, I met the American Academy of Orthopedic Surgeons meeting this week. We are as a company and we had a presentation at the Academy on Integrity Today that was standing room only. And have been very busy at the booth with a lot of interest. This is This product is really a technology that is addressing a lot of unmet needs that are getting surgeons excited. So it's much broader than like a handful of key surgeons that are using it at this point.

Okay. All right, great. And then just turning to Singhal and forgive me if I missed this in the prepared remarks, but in terms of the go forward, do you have any timetable as far as when the current nonclinical testing when that might be completed? Yes.

We haven't given an updated timetable because we just had this Type C meeting with FDA to get questions answered and make progress on finalizing the bioequivalence study design. Once I get formal feedback from FDA and I have information that I can then further communicate, that will give me kind of the last bit that I need around the two filing issues that we know we have we're addressing with toxicology studies, bioequivalence studies. And that's going to put me in a position to give a timing update as soon as we have that information back from FDA.

Okay.

And then Steve, I guess in terms of the longer term the longer term guidance for revenue. The commercial channel you have sort of picking up from sort of 17 percentage the last few years on average to 20% to 30% in the out years. And I'm just curious is that an acceleration of integrity? Like what what sort of goes into that pickup? Yes, it's a great question. This year, I'd say the largest piece of the growth is going to come from integrity. And then we'll also have some continued growth from the international OA pain I mean, international OA pain for us has been a real bright spot. That's the lion's share of the growth of that 17% CAGR the last couple of years. We'll see it moderate to some extent this year. But when we get to 26, what we'd expect to see is sort of that again, slower growth on international away paying, continued growth on integrity and then the introduction of Hiala Fast in the fourth quarter. And then by 2027, that 20% to 30% range is really going to be mostly driven by the introduction of Hylofast. That would be the first full year after the FDA approval.

Okay. So that actually includes okay, we're going to model or at least forecast revenue from Hilo Fast in late 'twenty six.

Yes, that's correct. I mean, it's not a material amount of revenue. But it does contribute. And then we'd expect to see it kind of kick in in 2027. So I think in total what you're looking at is integrity on the market today really doing an excellent job. Our teams and the surgeons have really I think found a great product here. We'd expect to continue to take market share as we go through 'twenty five and then into 'twenty six and 'twenty seven. And then in 2027, you really start to see more contribution from Hialeah Fast.

Okay.

All right. All right. Sounds good. Thank you guys. Appreciate it.

Thanks, Mike.

Thank you. Ladies and gentlemen, this concludes our question and answer session as well as today's We would like to thank you for taking the time to attend. And you may now disconnect your lines.