Investors Eye Risk as Leveraged Biotech ETFs See Divergent Returns Direxion’s leveraged biotech ETFs, LABU and LABD, continue to draw attention for their amplified daily moves. LABU has recently outperformed broader markets over two weeks, while LABD has lagged. Both funds, designed for sophisticated traders, track the S&P Biotechnology Index and are unsuitable for passive, long-term investors due to leverage risk.32