Orchestra BioMed Reports Increased Losses and Higher R&D Spending for 2024 Orchestra BioMed posted a net loss of $61 million in 2024, up from $49.1 million a year prior, as research and development expenses rose 27%. Revenue slipped to $2.6 million, largely due to lower partnership income, while cash reserves stand at $66.8 million, covering roughly 16 months of operations.34