Quantum-Si incorporated Price & Performance (QSI)

Good afternoon, everyone, and thank you for joining us. Earlier today, Quantum SI released financial results for the fourth quarter and full year ended December 31, 2024. A copy of the press release is available on the company's website. Joining me today are Jeff Hawkins, our President and Chief Executive Officer as well as Jeff Kies, our Chief Financial Officer. Before we begin, I would like to remind you that management will be making certain forward looking statements within the meaning of the federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward Looking Statements of our press release.

For a more complete list and description of risk factors, please see the company's filings made with the Securities and Exchange Commission. This conference call contains time sensitive information that is is accurate only as of the live broadcast date today, March 3, 2025. Except as required by law, the company disclaims any intention or obligation to update or revise any forward looking statements. During this call, we will also be referring to certain financial measures that are not prepared in accordance with U. S. Generally Accepted Accounting Principles or GAAP. A reconciliation of these non GAAP financial measures to the most directly comparable GAAP financial measures is included in the press release filed earlier today. With that, let me turn the call over to Jeff Hawkins. Good afternoon, and thank you for joining us. On today's call, we will provide a business update, review our operating results for the fourth quarter and full year of 2024, and provide our initial thoughts on 2025. After that, we will open the call for questions. I will begin with a reminder of our three corporate priorities. To accelerate commercial adoption, to deliver on our innovation roadmap and to preserve our financial strength, Our first corporate priority is to accelerate commercial adoption. 2024 was an important year in the commercialization of our Nexo generation protein sequencing technology and platinum instrument.

The year began with our transition into a full commercial launch at the end of the first quarter followed by consistent quarter over quarter revenue growth throughout the year and concluded with our first quarter in excess of $1,000,000 in revenue. Along the way, we significantly diversified our customer base from one that entered the year made up of largely academic researchers in The United States a customer base spanning multiple market segments and geographies. Today, our customer base has a healthy mix of academic, [indiscernible] government and contract research organizations In addition, we built an international distribution channel that currently has 18 partners, giving us access to an attractive growing global market opportunity for our products. I am pleased with how we closed out 2024 with total revenues of $1,200,000 in the fourth quarter and $3,100,000 for the full year 2024. These results represent a 52% increase in revenue over the third quarter of twenty twenty four and a 183% increase in annual revenue on a year over year basis. The changes we made to our commercial strategy throughout 2024 paid dividends in the fourth quarter as we observed greatly improved commercial execution across all aspects of our strategy from lead generation to sales execution delivering our strongest quarter ever in terms of both revenue and new instrument sales.

We are also pleased to report that during the fourth quarter of twenty twenty four, we achieved a significant milestone having sold our fiftieth Instrument, In addition to nearly tripling revenue in 2024, as compared to 2023, we also executed on key distribution agreements for our products globally. As announced in November of twenty twenty four, entered into a distribution agreement with Avantor for the North American market.

This agreement augments our current direct sales efforts and once fully implemented significantly increases the number of sales professionals actively engaged in selling our products across all end user markets in North America.

We are currently in the sales training and implementation phase of this relationship and expect to complete this process during the first quarter of twenty twenty five. Turning now to our global channel, we exited The international expansion we executed on during 2024 added coverage to our existing direct and distribution footprint in Western Europe Eastern Europe and Asia and expanded our presence into new countries within The Middle Africa, South America and the South Pacific regions.

While we are still in the early stages of our international commercialization efforts, we are very pleased with the initial end user traction we are seeing as well as the interest in our platform in general. One key learning from the early commercialization effort is that despite a rapidly growing interest in proteomics research in these regions, the cost of many of the legacy ProtodioMx instruments makes them inaccessible to many researchers. Platinum's low capital cost simplified workflow and automated data analysis provides a realistic option for researchers in these regions looking to integrate an advanced proteomics platform into their research. We are optimistic that this is an early indication the potentially compelling international opportunity for our technology and we plan to continue to build out our international channel network to fully capture this emerging opportunity in 2025 and beyond. In addition to our focus on commercial execution during 2024, we established a dedicated scientific affairs team to work directly with customers and key opinion leaders to publish and present data demonstrating the value of next generation protein sequencing. In addition to the focus on external data generation, scientific affairs team works closely with our commercial and R and D teams to publish data about specific aspects of our technology, like data analysis or specific applications of our technologies like protein barcoding.

Over the course of December of twenty twenty four, and January of twenty twenty five, four manuscripts were submitted for peer review and in parallel published as preprints on BioRxiv. The first paper was from our R and D team and covered our new protein barcoding kit including the work flow and analytical performance validation results.

Importantly, the validation data determined a lower limit of detection as low as 50 femtomole and a tenfold dynamic range demonstrating the method sensitivity in detecting low abundance variants. The second paper was also from our R and D team and was focused on ProteoView, our comprehensive bioinformatics pipeline for single amino acid variants. The study described in this paper demonstrates the ability of ProteoView to perform robust single amino acid variant detection and quantification with applications ranging from proteoform characterization to protein mixtures and quality control assays. The third paper was from researchers at the University of Virginia. This foundational study illustrates the capacity of next generation protein sequencing to detect proteoform variation at the single amino acid level including variants associated with disease phenotypes that are not detectable with existing technologies like mass spectrometry. And finally, the fourth paper was from researchers at Northwestern University, This study highlights the synergy of complementary protein detection methods in this case mass spectrometry and next generation protein sequencing to more comprehensively characterize proteoforms relevant to biological interactions. We are excited to see these first four manuscript being submitted for peer review publication and expect that trend to continue throughout 2025 as our scientific affairs team is actively engaged with researchers across a broad range of applications and market segments, to publish the results of their ongoing research.

Finally, I am pleased to announce that we have formed a world class scientific advisory board led by Doctor. Gloria Shankman from the University of Virginia. Our Scientific Advisory Board is made up of an outstanding group of scientists from academic research and industry that bring deep experience with protein and DNA sequencing, protein modifications in relation to disease, bioengineering, molecular delivery systems as well as consumable development and product development. I would encourage you to visit our website to learn more about our Scientific Advisory Board members. We look forward to collaborating with this distinguished group of scientists as we continue to expand the utility, utilization of next generation protein sequencing in the global proteomics market. Our second priority is to deliver on our innovation roadmap. Over the course of 2024, our R and D team delivered two new sequencing kits a new library prep kit a bar coding kit and two new software workflows, specifically protein inference and a single amino acid variant detection and quantification tool called ProteoView. At a high level, the kit launches expanded our proteome coverage significantly reduced the sample input amount required and improve the overall sample success rates across the broad range of proteins and applications.

When combined with the software workflows, customers experience a consistent flow of new capabilities that allowed them to pursue an ever increasing range of protein analysis applications sample types and proteins of interest In addition, in January, we announced the launch of Platinum Pro with shipping expected to begin during the first quarter of twenty twenty five. Platinum Pro is an evolution of Platinum that offers a streamlined and more efficient processing experience for the user, the ability to process data on board or in the cloud, and includes ProMode, enables customers to develop custom applications using the power of our single molecule kinetic detection technology. Next, I would like to provide a recap of the innovation roadmap we laid out at our Investor Day on 11/20/2024. First, we reviewed the proteomics market and the long term growth drivers. The proteomics market is a large important and growing market, which is still in its relative infancy. Some examples of the long term growth drivers we shared include large scale screening studies that once completed drive the need for follow on studies to more deeply characterize the most clinically and therapeutically actual proteins identified. Additionally, the move to greater use of artificial intelligence tools whether in drug development, protein engineering, or multiomics analysis will require vast amounts of data to be generated to train the models.

In both cases, we believe that tools like next generation protein sequencing will be a key tool to drive these research initiatives forward. Second, we laid out a new instrument and consumable other technology development initiatives creates a clear path to de novo sequencing. The Proteus platform will be the first platform to incorporate this new architecture and we expect Proteus to launch in the second half of twenty twenty six. At a high level, Proteus will offer significantly more reads per sample, more samples per run, and greater workflow automation than our current platform. As an example, our current platform Platinum processes a single consumable per run and that consumable contains 2,000,000 wells. Proteus is being designed to process two consumables at a time and each consumable is expected to contain up to 80,000,000 wells for a total of 160,000,000 wells per run.

This expanded number of wells can be used to process more samples per run or can be used for extremely deep analysis of a single or small number of samples. From a development perspective, the Proteus program is derisked compared to a typical new platform development project in two ways. First, we can utilize many aspects of our current commercially available technology such as surface chemistry, consumable fabrication methods, library prep and sequencing chemistry. And second, we can take advantage of the advancements in the field of optics that have been developed over the past decade to meet the needs of next generation DNA sequencing platforms. Finally, we shared data from our research initiatives that showed the vast capability of our core technology to be extended into other areas of proteomics beyond protein sequencing. Based on the data presented, we believe our core technology is the only commercially available technology that can enable single molecule top down and bottoms up proteomics methods. In summary, we believe that our Proteus platform and core technology are capable of addressing the broadest range of proteomics analysis methods of any technology in the market today. We expect to unlock that potential through a combination of both internal R and D initiatives as well as strategic partnerships to ensure that Proteus will enable every lab to be a core lab without the need to own multiple instruments or have specialized facilities and staff to perform proteomics research.

If you would like to learn more about any of these topics, I would encourage you to visit the Investor we have a comprehensive slide deck and audio recording of the full event. In the coming months, we will certainly provide you updates on the Proteus development process to allow you to understand our progress relative to our anticipated launch date in the second half of twenty twenty six. The key milestone this year is successful protein sequencing on a prototype Proteus system by the end of twenty twenty five. We certainly have numerous other incremental milestones and as those items come up, we will provide you updates as appropriate. Additionally, for 2025, we announced today that we expect to launch a Version four sequencing kit in the third quarter of the year. We expect that this new sequencing kit will further increase proteome coverage and protein accessibility via new recognizers and cutters. We are also continuing to advance other product development initiatives across library prep, application development and software, and we expect to provide updates to you in the coming months on these programs. Our third priority is to preserve our financial strength. We remain committed to utilizing our capital in the most efficient manner that maximizes shareholder value.

We will continue to be nimble adjust our capital deployment strategy as the business or market may require. To that end, post our Investor Day presentations and partnership announcements in November of twenty twenty four, we observed a significant increase in interest from investors as the long term strategy was now clear and the market was able to better understand the full potential of our uniquely differentiated technology. Based on this market interest, we raised capital through our at the market facility in December as well as raising additional capital at the January. Jeff will go into more details, but the combination of these capital raises effectively provides us another year of cash runway as we work to execute on our commercial strategy and innovation roadmap.

I will now turn the call over to Jeff to review our financial results. Thanks, Jeff.

Now I'll review the details of our operating results for the fourth quarter and full year 2024.

Revenue in Q4 twenty twenty four was approximately $1,200,000 which consisted of revenue from our platinum instrument consumable kits and related services. Gross profit was $610,000 and gross margin was 51%. As I have been saying throughout 2024, our gross margin percentage will be somewhat variable for the foreseeable future as we work through our continued commercialization efforts and may be impacted by the timing and mix of instruments versus consumable sales. Our margin has also been impacted and may continue to be impacted by the acquisition costs and any accounting adjustments to underlying inventory that predates the commercial launch of the platinum line of instruments.

Our gross margin for Q4 twenty twenty four includes approximately a 2% benefit for inventory utilized during the quarter that was carried at low or no value and dates back to prior to the initial commercialization. We do expect to see more variances that will flow through our [indiscernible] and I will highlight them if they are material.

Revenue for the full year 2024 was $3,100,000 and gross and gross margin was 52%. Similar to the comment I just made about Q4, our gross margin for the full year 2024 includes approximately a 3% benefit for inventory utilized during the quarter that was carried at low or no value. Turning to operating expenses, GAAP total operating expenses for the fourth quarter of twenty twenty four were $31,300,000 compared to $28,100,000 in the fourth quarter of twenty twenty three while adjusted operating expenses were $26,700,000 for the fourth quarter of twenty twenty four, compared to $26,300,000 for the fourth quarter of twenty twenty three.

Overall, we have essentially kept our adjusted operating expenses flat while funding the ramp up of our commercial operations. For the full year 2024, our GAAP total operating expenses were $110,200,000 compared to $111,700,000 in the prior year a decrease of about 1%. Included in total operating expenses are R and D and SG and A [indiscernible] R and D expenses were $59,600,000 in 2024 compared to $67,000,000 in 2023 eleven percent decrease year over year. SG and A expenses were $50,500,000 in 2024 compared to $44,600,000 in 2023 an increase of 13%. As a reminder, we executed an R and D realignment in August of twenty twenty three that streamlined our R and D efforts on focused product delivery to the market, a portion of the year over year decrease is the impact of the 2023 restructuring program. In addition, in November 2024, we initiated a corporate wide restructuring program to streamline and focus corporate resources, as well as align required resources to focus on our recently announced Proteus platform development. All in all, the year over year change in R and D expenditures reflects the impact of the aforementioned restructuring programs, While the optimization activities in November 2024 are expected to align and optimize spend, on our core R and D programs, including proteus development, while keeping forward total R and D spend roughly equivalent to 2024.

Overall SG and A expenses increased year over year as planned the majority of the year over year increase in Q4 twenty twenty four as we ramped up our commercialization efforts. Stepping back is important to note that we have kept overall operating expenses and adjusted operating expenses flat year over year while at the same time delivering multiple products to the market initiating and funding a game changing development program with Proteus and funding our commercial operations ramp. Our dividend and interest income in the fourth quarter of twenty twenty four was 2,200,000.0 compared to $2,300,000 in the fourth quarter of twenty twenty three. For the full year 2024, dividend and interest income was 11,400,000.0 compared to $9,500,000 for the full year of 2023. Overall, we benefited year over year from higher interest rates relative to our overall cash, cash equivalents and marketable securities position. As of 12/31/2024, we had $209,600,000 in cash and cash equivalents and investments in marketable Included within the $209,600,000 are the gross proceeds from our ATM facility raised in the fourth quarter of 36,200,000.0 not included in the $209,600,000 is the gross proceeds from our capital raise that closed on January 6, 2025 of $50,000,000 Taking into consideration the $209,600,000 of cash, cash equivalents and marketable securities in 12/31/2024, and the gross proceeds of $50,000,000 from our capital raise on 01/06/2025 as well as our continued financial discipline and focused efforts on capital allocation, we expect to have cash runway into the second half of twenty twenty seven.

For 2025, there are two key activities that are evolving that currently limit our full view into 2025 revenue that we are tracking against.

These two items are our Avantor distribution relationship in North America and the current uncertainty surrounding the NIH funding environment for 2025. As Jeff mentioned earlier, we are working through the process of training and onboarding the Aventor organization which we expect to be complete by the end of the first quarter. Once these onboarding activities are completed, and initial traction on sales are observed, we will have more clarity on the full impact of Now turning to the NIH funding environment, As many of you have already heard from other companies in the life science tools space, there is uncertainty regarding NIH funding that has the potential to impact academic research market in The United States.

The degree of this impact is hard to predict until the NIH budget and spending priorities are finalized by the new administration.

On a positive note, our international opportunity and our U. S. Opportunity in other market segments such as pharma and biotech are all not expected to be impacted by the NIH funding uncertainty. Having said that, for the first quarter twenty twenty five, we anticipate revenue to be at least $900,000 This level of revenue represents approximately 100% growth year over year in the first quarter and takes into account the typical drop off in life science tool companies seen in terms of quarter over quarter revenue when moving from Q4 into Q1 minimal contribution from Avintour and the uncertainty around A and IH funding and the potential to delay some academic customers in The U. S. Market from finalizing their capital spending plans for 2025.

Turning to adjusted We're able to provide more clarity based on our past run rates continued corporate efficiency initiatives and our development roadmap. Our preliminary guidance for [indiscernible] and total estimated cash used for 2025 will be $95,000,000 or less.

Now I'll turn the call over to the operator to open the line for questions. Our first question comes from the line of Kyle Nixin from Canaccord Genuity.

Your question please. [indiscernible] Kyle McKinnon, your line is open. Hey, guys. Thanks for the questions. So you launched the Pro system in January. Did you sell any since the announcement? And how has that impacted sales of the legacy platinum boxes and consumables since Yes, Kyle. So as you said, we announced the launch of Platinum Pro in earlier this quarter. We expect to start shipping the machine before the end of the quarter. We're not sort of giving out a specific number of machines at this point. We haven't seen any impact right now on the the platinum sales, there's obviously two different price points of those devices. So some people may still acquire the platinum while it's available and others may move directly to pro.

And given the consumables are the same across the machines, we also haven't seen any impact on consumable ordering patterns of platinum users, even those who may be considering sort of an upgrade in the future a Platinum Pro.

Got it. Thanks, Jeff. And I just want to confirm, actually I got to take a step back. I know that you guys kind of provided expectations for essentially quarterly revenue going forward. But was any of this $1,200,000 in the fourth quarter, was that pushed 3Q or maybe pull forward from the first quarter of twenty five Nothing was pushed from Q3. I think we certainly saw some end of year buying decisions occur in the fourth quarter. I wouldn't say it was sort of a significant level of those I wouldn't go as far as calling it a budget flush, but there were certainly some folks who knowing that platinum would likely see a price increase and that we had announced that Platinum Pro was coming in the first half of the year back at our Investor Day in November of twenty twenty four. We did see a few areas where we believe customers may have pulled those purchase decisions forward. But again, not a significant trend in either direction.

All right. That makes sense. And again, I think this was sort of a little bit in the guidance expectations, but would you mind kind of clarifying the expectations for the Avon Tour Port partnership this year, like is that pivotal for some of the, essential targets that you have Yes. So on inventory again, we signed the distribution agreement in November of twenty twenty four. As a standard in these types of distribution agreements, we have a phase where we're implementing our products into their operating system so that they can be ordered and fulfilled through the system. And then we have the training of the sales professionals. So sort of meetings that were set up throughout the first quarter of the year as is typical with commercial organizations. So we've been slotting into those meetings and providing training for the teams and now the teams as they get trained are out beginning to interface with our direct reps and really strategize and coordinate at a territory level. So as we said when we announced the distribution agreement, we expected Q1 to really be that training and implementation phase. We expect to see some contribution from the relationship in the second quarter of the year and really see more of the acceleration from that relationship in the back half of the year after their reps have been trained and been out in the territories for a period of time to build their funnels and ultimately able to deliver more of a ramp in the second half of the year.

Got it.

Okay. And then in light of the recent the U. S. Hoopla and the AGBT conferences, can you just talk about the recent feedback from both the proteomics and the genomics communities and how they're sort of interacting so far with the technology and the kind of value proposition?

Sure. I think at AGBT, which is obviously a more focused show in genomics next generation DNA sequencing, some of the spatial technologies There were obviously a lot of new product announcements or new new entrants into the space. So lots of lots of competitive noise in the space, certainly within the genomics field.

NIH funding was certainly a hot topic amongst the academic researchers So not normally a core event for us. So we we never expected to be a huge source of sort of what we would call more lead generation or marketing activities, but we did have people there I mean, attendance presenting scientific data and posters on the technology. And we had very good traffic at those poster sessions, lots of great questions from people really in that community thinking about that multi omic workflow. How do they go from RNA sequencing and incorporate proteomics technologies to sort of close that that loop, very similar to what University of Virginia talked about in their paper that was preprint on bioRxiv. So that's maybe a good analog of sort of how the geomx community at that meeting was interfacing with us with a protein sequencing technology HUPO obviously a very targeted event, nowhere near the size of AGBT, but very focused on the proteomics market, the proteomics customers. We had tremendous booth traffic there. We had interest at posters that were a mix of some data we presented, also data that customers presented. Other workshops and activities. So So very positive feedback we're getting each time we bring out new capabilities.

That gets people talking about new applications. And ultimately in these events as we've talked about on these calls before, a mix of customers presenting data and some of that peer to peer exchange of information is a very valuable tool in driving the awareness and ultimately the adoption.

All right. Maybe on that note, would you mind like maybe at relatively high level, could you talk about why the amino acid binder like well based approach why you're confident that's going to be successful here relative to like a nanopore based approach that we've seen, just coming off of the Roche kind of comments, I guess, always move ADBT things like that. Just why is like your approach better vision, but potentially versus something that we've kind of seen in like more of an R and D kind of like phase Yes. Well, I think Kyle, a little hard to know exactly how to compare to Nanopore based approaches for protein sequencing given there aren't any commercially available products that utilize that technology. And there are certainly some very early stage research papers that have been published on trying to apply nanopore technologies. But most of those papers as is often the case with early development, are focused on on very simple samples perhaps amino acids with spacers and then to improve accuracy or the ability to detect the changes in amino acids. So So a common technology feasibility approach, but not necessarily something that we know that what the specs would look like in a commercial environment and how about positioning our technology against that.

I think what we're focused on with our approach is Unlike DNA, where nanopores have been applied, you have four DNA bases to deal with everything is negatively charged. In amino acids, we're talking 20. We're talking about a wide range of properties of those amino acids and the sequence context of those amino acids a very challenging endeavor. So while perhaps NanoFours will get there, we think it's a significantly harder challenge than perhaps DNA in nanopores. In terms of how we focus on our approach, we like about our approach is a couple of things. One is our amino acid recognizers are capable they typically detect two or three amino acids and the relevant sort of post translational modifications or changes, that approach will prevent us from needing to have 20 different recognizers, which we think trying to scale up to these really large numbers of potential recognizers would be a very difficult biochemistry problem. So sort of our kinetic detection and that ability to have these multi affinity sort of recognizes for different amino acids we think is definitely an advantage from a development perspective. [indiscernible] when we talk about sort of the engineering architecture, what we like about the direction we're going with Proteus is we really put ourselves on consumable architecture that can be scaled to billions of reads sort of the type of [indiscernible] and then you're really leveraging a lot of the optical detection technology capability that's been evolved over the last decade or so.

So we really like that sort of trying to leverage a lot of that capability that's out there getting onto that architecture that we'll Gail [indiscernible] underpinned by sort of our unique genetic detection with those amino acid recognizers.

Perfect.

And then maybe just on that last note and just to be final question for me. Could you maybe confirm if the Proteus architecture and the initial assays is locked down? Like how is that progressing? I know you have the second half of next year launch, but in terms of like some of the technical milestones, how are those going?

Yes. So good question, Kyle. So maybe I'll start with what we said in the call, which is our key milestone we want to achieve this year is that we demonstrate our next generation protein sequencing chemistry on that Proteus platform and the consumable on sort of a prototype of that platform and consumable. So that we expect to do by the end of the year. I'd say a couple of things about sort of how we're progressing, right? So at our Investor Day, we showed some of the early technology feasibility data around the consumable fabrication method, the change from lifetime detection to color ratio So that was some of that early data we talked about the partnerships we did to help derisk and accelerate. So SkyWater around the consumable planet innovation around the instrument NVIDIA around AI and compute and then more recently you probably saw that we partnered with IDEXX Health and Sciences really the leader in high performing optical systems in the life science space. So we feel really good about the partners we have around us sort of how the technology has progressed from what we showed in November and are very confident we can get to that goal of having sequencing on a prototype flat right where we'd want to be in terms of getting to that second half of 'twenty six launch.

So as we go this year, we'll certainly provide other updates, but really right now, progressing the way we like set up well for that end of year milestone and assuming we hit that really gets us then to that second half 'twenty six launch. Got it. Okay. Thanks for the help.

Thank you.

Thank you. And our next question comes from the line of Douglas Macpherson from H. C. Wainwright. Your question please. Hi there. Nice to speak with you and congrats on a good quarter. Thanks, Doug. So similar to what was touched on by the last caller, I recall last quarter there was some some variability in the sales cycle, sometimes taking a little bit longer than expected.

As you're gaining more experience with more customers, are you starting to see an experience sort of a more predictable cadence to those sales cycles?

Yes. Good question, Doug. So I think the sales cycle, we're we're seeing is certainly longer than it has been historically. In our market for an instrument of a similar price. I think we're comfortable with now what that sales cycle looks like and that we're seeing it consistently, but it is still elongated from what it's historically been in our space for a device of this sort of price point.

Sure.

Thank you for that. And then as far as target markets, you said mostly it's been academic researchers, but you're sort of branching out and getting some traction with CMOs, biotech, large pharma government. What do you see as the largest market? And are there any markets that you find it a little difficult to crack and it's feel like it's an untapped market and maybe would like to to undertake some initiatives in order order to penetrate into those markets.

Yes. So two questions there, Doug. Let me take the first one. So as we exited 2023, our customer base, as I said on the prepared remarks, was largely academic, right? As we exited 2024, it's about a fifty-fifty split now between academic customers and those academics are both in The U. S. And in Western Europe. And then those other segments, pharma, biotech, government. So So really good diversification of that base of customers We'd expect that diversification to continue as we go forward in terms of more and more of those biotech pharma etcetera sort of coming online The second part of your question Doug, was more about the untapped opportunities. So I think the key one right now that we see line of sight to given the diverse [indiscernible] really is that international opportunity. We had a couple of partners earlier in the year and then added to that international distribution channel over the course of 2024.

And I think as I said in the prepared remarks, really seeing an interesting opportunity in these other regions of the world where perhaps they don't have the capital to buy a 500,000.0 or $1,000,000 piece of equipment. They don't have the infrastructure scientifically or bioinformatically to analyze the data and do the laboratory workflow. So really feel like there could be a nice opportunity across multiple end segments within that ex sort of OUS or outside The United States sort of opportunity through those channel partners That's why we built into that network over the course of 2024 and we'll continue to do that in 2025. Really feel like that's more of the untapped opportunity right now because I think the diversification of the base in general is going well in all regions and we continue to sort of push on that and invest in that sort of that distribution or decentralization of the customer base. Cool. All right. Thanks for the color on that. And then last one for me. Beyond the Avantor agreement, recall you had intended to do some internal expansion of your own commercial team Have you brought on a lot of new people? And then sort of what phase are they in?

Are they still under that whatever was three to six months of training or are you starting see them out in the field and even sort of delivering a return on that investment from your internal commercial teams?

Sure. Yes, good question. So we did do some additions to close out the year and right into the start of this year. As we sit here right now on this call, we have our sort of our commercial team, our direct team sort of staffed the way we expected it to be staffed for this point in 2025. Now obviously, we expect there to be some modest hiring throughout the year as we continue to scale up. Some of that could be in the sales types of roles, but also in the application support and sort of the that more scientific and based support and service as that installed base keeps growing. In terms of where are they at in the process, the majority of those sales professionals are in territory and have been out there now at least that three month period, but there are some that came on later in the year or came on first thing this year that are still in that training and ramp up phase.

So over the course of the next quarter or so, all those folks will sort of be at an operating scale. And then anybody who would come on new obviously would go the same type of training and funnel build and progression.

Okay.

So we might sort of see that impact in the back half of 2025, similar to the eventual agreement?

Yes, I agree with that. I think that I would say two things about it. One is our reps are getting are in that phase of being in the the territory working their funnels and working their space. They're now interfacing with those Avantor reps who just got trained. So we should start to see some of the synergies of those groups working together to sort of share leads and build the pipelines as we get into the back half of the year. Similar with our international channel partners, many of those came on in the second half of the year. We just held a big channel partner training meeting last week. So those folks now are getting more and more engaged with the tech, getting trained, getting their applications support people up to speed and we should see those folks out now able to start to build their funnels and then execute on on winning new customers as we move into the second quarter and second half of the year.

Thank you, ladies and gentlemen. That does conclude the question and answer session of today's program. I'd like to hand the program back to Jeff Hawkins for any further remarks.

All right. Thank you. We are excited about the progress during 2024 and are looking forward to delivering on our commercial scale up and technology roadmaps during 2025. Look forward to providing you more updates on our next call. Thank you for attending.

Thank you, ladies and gentlemen, for your participation in today's conference. This does conclude the program. You may now disconnect. Good day.