How is buyrate used by neurons

Butyrate, a short-chain fatty acid, has been found to play a role in the functioning of neurons. Here's how buyrate is used by neurons:

Regulation of Sympathetic Nervous System Activity: Butyrate directly regulates GPR41-mediated sympathetic nervous system activity, which helps control body energy expenditure and maintain metabolic homeostasis
1
.
Energy Substrate: Butyrate can serve as an energy substrate for colonocytes, which are cells in the colon. They have adapted to use butyrate as their primary source of energy
2
4
.
Neurogenesis: Butyrate has been implicated in the process of neurogenesis, which is the production of new neurons. This process primarily occurs in the hippocampus, a region of the brain responsible for learning, memory, and spatial navigation. Butyrate helps in the growth of new neurons in the hippocampus, which is associated with better pattern recognition and cognitive skills
3
.
Anti-Inflammatory and Neuromodulatory Effects: Butyrate has anti-inflammatory and neuromodulatory effects, which can help protect neurons from loss and promote their proper functioning
6
.

It's important to note that while these findings suggest a potential role for butyrate in neuronal function, further research is needed to fully understand the mechanisms and implications of its actions on neurons.

Sources

·

·

·

Answer

Related